Fig. 1.

To scale schematics of PDYN (a) and OPRK1 (b). Shown are functional sequence variants associated with psychiatric disorders (e.g., rs35286281) and transcriptional control proteins implicated in the regulation of these genes (positioned relative to the transcription start sites). Transcriptional control proteins for which there is in vivo evidence of binding are depicted above the sequence (e.g., REST), and those for which only in vitro evidence is available below the sequence (e.g., AP-1). ║ genomic regions omitted for clarity, boxes exons, white boxes coding regions, black arrows transcription start sites, green arrows alternative transcription start sites