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The inhibitory mechanism of Notch signaling by BCL6/BCoR complex. Transcriptional repressor B-cell lymphoma 6 (BCL6) is recruited to promoters of selected Notch target genes in a sequence-specific manner through an unknown mechanism. Once BCL6 binds to promoters, BCL6 competes with MAM for ANK domain of NICD and blocks the interaction between NICD and MAM. Subsequently, BCL6 recruits BCL6 co-repressor (BCoR) and inhibits Notch-dependent transcription.
