Table 2.
MYST acetyltransferases in major model organisms
| MYST proteins | KAT5 | KAT6 | KAT7 | KAT8 |
|---|---|---|---|---|
| S. cerevisiae | Esa1 | Sas3 | Sas2 | |
| S. pombe | Mst1 | Mst2 | ||
| C. elegans | mys-1 | mys-3 mys-4 | mys-2 | |
| D. melanogaster | dTIP60 | ENOK CG1894 | CHM | MOF |
| M. musculus | TIP60 | KAT6A/MOZ/MYST3 KAT6B/Qkf/MORF/MYST4 | HBO1/MYST2 | MOF/MYST1 |
| H. sapiens | TIP60/PLIP | KAT6A/MOZ/MYST3 KAT6B/MORF/MYST4 | HBO1/MYST2 | MOF/MYST1 |
| Associated domains | Chromodomain | PHD fingers | Zn finger | Chromodomain |
| Histone specificity | H4/H2A | H3 | H4 > H3 | H4K16 |
| Roles | Gene regulation, DNA damage repair/response, development/stem cell renewal, essential for cell viability | Gene regulation, development/stem cell renewal | Gene regulation, DNA replication, chromatin boundary, development | Gene regulation, DNA damage response, dosage compensation, chromatin boundary, early development |