Fig. 1.

Overall structure of the human Cx26 gap junction channel in ribbon representation. a Side view of the Cx26 gap junction channel with the locations of plasma membranes and scale of each region. Each subunit is colored differently, and those associated with the crystallographic two-fold axis are in the same color. b Top view of the Cx26 gap junction channel representing the arrangement of the transmembrane helices and the N-terminal helix. The channel has a hexagonal appearance with the largest outer diameter of ~90 Å and a pore entrance of ~40 Å