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Schematic representation of the effect of aspirin on membrane-receptor trafficking. Upon binding to ligand, EGFR and TfnR are endocytosed into early endosome and then moved on to the sorting platforms. Enhanced recruitment of SNX3 and possibly SNX5 to AMC upon aspirin treatment delays the lysosomal degradation of EGFR as well as recycling of TfnR to the cell surface
