. 2011 Nov 9;69(9):1493–1503. doi: 10.1007/s00018-011-0880-6

Table 1.

Consequences of cell cycle regulatory molecule deficiency on neurogenesis in postnatal, young and old adults in vivo and in vitro

		Postnatal (P1 < P10)		Adult (P42 < P120)		Old adult (1 year < 2 years)
		In vitro	In vivo	In vitro	In vivo	In vitro	In vivo
Cdk2^−/−	DG	N.D.	N.D.	N.D.	No change in NPC proliferation	N.D.	N.D.
Cdk2^−/−	SVZ	No change in neurosphere number	No change in NPC proliferation	Reduced neurosphere proliferation and self-renewal	Reduced NG2 + cell proliferation	N.D.	N.D.
Cdk4^−/−	DG	N.D.	No change in NPC proliferation	N.D.	No change in NPC proliferation	N.D.	N.D.
Cdk4^−/−	SVZ	N.D.	No change in NPC proliferation	N.D.	No change in NPC proliferation	N.D.	N.D.
Cdk6^−/−	DG	N.D.	Reduced NPC proliferation	N.D.	Reduced type -2b and -3 NPC proliferation	N.D.	N.D.
Cdk6^−/−	SVZ	N.D.	Reduced NPC proliferation	N.D.	Reduced type -2b and -3 NPC proliferation	N.D.	N.D.
Cyclin D2^−/−	DG	N.D.	No change in NPC proliferation	Some neurospheres are formed	Absent NPC proliferation	N.D.	N.D.
Cyclin D2^−/−	SVZ	N.D.	N.D.	N.D.	Absent NPC proliferation	N.D.	N.D.
pl6^Ink4a−/−	DG	N.D.	N.D.	N.D.	No change in NPC proliferation	N.D.	No change in NPC proliferation
pl6^Ink4a−/−	SVZ	N.D.	N.D.	No change in neurosphere number nor self-renewal	No change in NPC proliferation	Increased neurosphere number and self-renewal	Increased type-B NPC proliferation
p21^Cip1−/−	DG	N.D.	N.D.	N.D.	Increased NPC proliferation	N.D.	N.D.
p21^Cip1−/−	SVZ	No change in neurosphere number	N.D.	Increased neurosphere number and self-renewal	Increased type-B NPC proliferation	Reduced neurosphere number and self-renewal	Reduced type-B NPC proliferation
p27^Kipl−/−	DG	N.D.	N.D.	Increased neurosphere number	Increased NPC proliferation	N.D.	N.D.
p27^Kipl−/−	SVZ	N.D.	N.D.	Increased neurosphere number	Increased type-C NPC proliferation	N.D.	N.D.
pl07^−/−	DG	N.D.	N.D.	N.D.	N.D.	N.D.	N.D.
pl07^−/−	SVZ	N.D.	N.D.	Increased neurosphere number and self-renewal	Increased type-B NPC proliferation	N.D.	N.D.
E2 fl^−/−	DG	N.D.	N.D.	N.D.	Reduced NPC proliferation	N.D.	N.D.
E2 fl^−/−	SVZ	N.D.	N.D.	N.D.	Reduced NPC proliferation	N.D.	N.D.

N.D. Non-determined