Fig. 1.

Sequence homology and domain organization of Dictyostelium TACC. Sequence homology of TACC family members is limited to ~250 C-terminal amino acids constituting the TACC domain. The sequence alignment of various TACC domain sequences from humans (hTACC1), Xenopus (Maskin) and Drosophila (D-TACC) with Dictyostelium TACC was generated with ClustalW (a). The domain organization of the three GFP fusion proteins generated in this work (b). The TACC domain is depicted as a pentagon and GFP as an ellipse