Table 3.

Involvement of major error-free DNA repair pathways in repair of DNA lesions induced by anticancer drugs

Drug class	Examples	DNA lesions	Error-free repair pathways
Monofunctional alkylators	Monofunctional nitrogen mustards Temozolomide	Base damage, adducts	HR, BER
Bifunctional alkylators	Bifunctional nitrogen mustards Platinum drugs	DSBs, adducts, crosslinks	HR, NER, FA
Topoisomerase I inhibitors	Camptothecins	SSBs, DSBs	HR
Topoisomerase II inhibitors	Anthracyclines, etoposide	SSBs, DSBs	HR
PARP inhibitors	Olaparib	SSBs, DSBs	HR
Replication inhibitors	Aphidicolin, hydroxyurea	DSBs	HR
Antimetabolites	Base analogs, antifolates	Base damage	BER, MMR

SSBs single-strand breaks, DSBs double-strand breaks, HR homologous recombination repair, BER base excision repair, NER nucleotide excision repair, FA Fanconi anemia, MMR mismatch repair