Fig. 1.

Schematic representation of the applied methodology for the selection of the target genes using data integration and comparative genomics. Starting from genome-wide Arabidopsis thaliana microarray data, an integrative strategy based on coexpression, functional enrichment analysis, and cis-regulatory element annotation was combined with a comparative genomics approach between plants and humans to detect conserved cell cycle genes involved in DNA replication and DNA repair processes. Numbers in parentheses report the number of genes that were retained after each step