Fig. 1.

Endocytic transport of membrane receptors for degradation. Receptors ubiquitinated at the plasma membrane are internalized and recognized by ESCRT-0. Recognized receptors are sequentially transported by ESCRT-I, -II and -III complexes, and internalized into luminal side of late endosomes to form multi-vesicular bodies for degradation. Deubiquitination occurs at early and late endosomes to regulate receptor degradation and ubiquitin retrieval, respectively