Table 1.

Comparison of CyrA to the matricellular proteins tenascin C and thrombospondin-1

Characteristics	Tenascin C	Thrombospondin-1	CyrA
Secreted	Yes [1]	Yes [1]	Yes [21, 54]
Localizes to the ECM	Yes [1]	Yes [1]	Yes; slime sheath [21, 54]
Expressed at high levels during development	Yes [1]	Yes [1]	Yes [21, 54]
Contains EGFL repeats	Yes [28]	Yes [29]	Yes [21]
Releases cleavage products	Yes [23]	Unknown	Yes [21]
EGFL repeats modulate cell motility	Yes [27]	Yes [29]	Yes [20, 21, 60]
EGFL repeats bind to the cell surface	Yes [26, 28]	Unknown	Yes [54]
Receptor	Yes; EGFR [26, 28]	Unknown	Yes; uncharacterized [54]
Initiates intracellular signal transduction	Yes [27, 28]	Yes [29]	Yes [20, 21, 60]