Fig. 3.

Angiogenesis and inflammation are reduced in neovascular lesions of Mmp13-deficient mice. Immunostaining was performed on samples from WT and Mmp13 ^−/− mice. a, b MMP13 immunostaining (day 14). PECAM (red) and NG2 (green) (c,e) or αSMA (green) (e,f) double immunostaining (day 14). g,h Labeling of inflammatory cells using CD11b antibody (day 5). i,j Staining of neutrophils (day 5). White bars represent 100 μm; yellow dotted line delineate the lesion; R retina, Ch choroid, inserts represent a twofold higher magnification of initial pictures