Fig. 4.

Bone marrow transplantation restores choroidal neovascular lesion formation in Mmp13-deficient mice. Mice were irradiated (recipient mice) and engrafted with bone marrow (BM) before laser-induced CNV. Quantification of lesions was performed by analysing the size of the lesions on choroidal flatmounts (a) and histological sections (b) (b/c ratio as described in “Materials and methods” and in Fig. 1). Recipient mice and BM engraftment are indicated below each graph. Number of impacts (N _i) per experiment group N _i = 8–12 (*p < 0.05, **p < 0.01; ***p < 0.001)