Fig. 3.

HDAC1- and 2-mediated repression of cell cycle regulators. a Recruitment of HDAC1 and 2 complexes to their target genes by various transcription factors in different cellular systems. Transcription factors (TF) are schematized as gray circles and nucleosomes as yellow circles, cellular systems and target promoters are indicated; red inhibition symbols indicate direct repression by deacetylation of histones at the indicated loci. b Schematic representation of indirect repression of the p21 promoter by HADCs via p53 deacetylation