Table 2.
MicroRNAs involved in angiogenesis driven by pro/antiangiogenic factors or tumor context
| Pro/antiangiogenic stimulus | microRNA | Targeta | MicroRNA function | Cell type | References |
|---|---|---|---|---|---|
| SCF | ↓miR-221 | c-kit | Inhibition of angiogenesis | Human ECs (HUVEC) | [76] |
| Quiescent, serum-depleted cells | ↑miR-221 | ZEB2 | Inhibition of proliferation | Human ECs (HUVEC) | [124] |
| IL-3 bFGF | ↓miR-221 | STAT5A | Inhibition of angiogenesis | Human ECs (HUVEC) | [128] |
| Serum, VEGF, bFGF | ↑miR-130a | GAX | Regulation of angiogenesis | Human ECs (HUVEC) | [127] |
| HOXA5 | |||||
| Cancer | ↓miR-15a-16 | FGFR1 | Inhibition of proliferation and angiogenesis | Multiple myeloma cell line | [129] |
| PI3KCa | |||||
| MDM4 | |||||
| VEGFa | |||||
| Hind-limb ischemia model, acute myocardial infarction | ↑miR-92 | ITGA5 | Inhibition of angiogenesis | Human ECs (HUVEC) | [131] |
| VEGF, bFGF cancer | ↑miR-132 | P120RasGAP | Promotion of angiogenesis | Human ECs (HUVEC), human embryonic stem cell vasculogenesis model | [132] |
| Cancer | ↑miR-296 | HGS | Promotion of angiogenesis | Human ECs (HBMVEC) | [133] |
| Cancer | ↑miR-93 | Integrin-p8 | Promotion of angiogenesis | Glioma cell line (U87) + ECs (Ypen) | [134] |
| Cancer | ↑miR-378 |
SuFu Fus-1 |
Promotion of proliferation and angiogenesis | Glioma cell line (U87) | [135] |
| K-Ras, Myc over-expressed | miR-17-92 | TSP1 | Promotion of angiogenesis | Mouse colonocytes | [138] |
| ↑miR-18 | SMAD4 | [139] | |||
| ↑miR-19 | CTGF | [138] | |||
| ↑miR-20 | TGFbR2 | [139] | |||
| TNF-a VEGF, bFGF | ↑miR-126 | VCAM1 | Leukocyte adhesion | Human ECs (HUVEC) | [141] |
| PIK3R2 (p85) | Promotion of angiogenesis | Human ECs (HUVEC) | [142, 143] | ||
| SPRED1 | Promotion of angiogenesis | Human ECs (HUVEC, HAEC) | [142–144] | ||
| PAK1 | Regulation of vascular integrity | Human ECs (HUVEC) | [145] | ||
| Cancer | IRS1 | Inhibition of proliferation (G0/G1 arrest) | Human breast cancer (MCF7), HEK293 | [149] | |
| VEGFA | Inhibition of proliferation (G0/G1 arrest) | Lung cancer cell lines | [150] | ||
| Human breast cancer (MCF7) | [151] | ||||
| CRK | Inhibition of adhesion, invasion, proliferation | Lung cancer cell lines | [152] | ||
| Gastric cancer cell line | [153] | ||||
| EGFL7 | Inhibition of proliferation | Lung cancer cell line | [154] |
aTarget validated by gene reporter assay