Fig. 1.

Conservation of NuRD-controlled archaic cell attractors represented by characteristic global pattern (GEDI) from RNAi-treated or knockout animals. Top a representative GEDI-maps during the timeline for wild-type C. elegans embryogenesis. Middle left b representative GEDI-maps of four mouse HSC tissue samples. Middle right c representative GEDI-maps of six samples from RNAi C. elegans. Bottom right d representative GEDI-maps of MEF MTA1 wild-type (upper) or knock out (bottom) samples. Bottom left e representative GEDI-maps of rep samples from Drosophila l(3)mbt ts mutant or wild-type. Note: GEDI-maps are for three randomly chosen tissue samples, showing the transcriptome patterns. Each map represents a transcriptome, with pixels representing the same genes in each map and their color is their expression level in the wild-type or experimental sample. Design of each RNAi or knock out treated sample is detailed as following: C. elegans: (1) The timeline for wild-type embryogenesis only. Embryonic cells are developmentally plastic until the 2E stage. At the ~8E stage, cells become committed to a cell fate. Focus from two-cells, 2E (24 cells), 4E (50 cells), and 8E (100 cells, onset of differentiation). (2) GFP is the control, proxy of wild-type animal, MEP-1/KLF4, LET-418/Mi-2β as experimental, proxy of deficient NuRDs. They are arrested at early L1. Mouse: (1) Mouse hematopoietic stem cell (HSC) differentiation. Mi-2β: control or conditional knock out. (2) Mouse embryonic fibroblast (MEF). MTA1: wild-type or knock out. Drosophila: l(3)mbt ts mutant or wild-type