Fig. 6.

Localization of CDK5RAP2 protein during the interphase and in mitosis. CDK5RAP2 protein is found at the centrosome and the Golgi complex during the interphase, and is localized at the centrosome in the mitotic cell (shown in tumor cells). Also, this protein has been localized to the plus end of microtubules. During the interphase cells are growing and duplicate their DNA (blue) in order to later divide during mitosis through the mitotic spindle apparatus (orange). Growth and division of cells needs a constant supply of new proteins and lipids to the site of synthesis in the endoplasmatic reticulum via the Golgi apparatus (green). During mitosis, the Golgi apparatus is fragmented into many small vesicles that are subsequently divided upon the later daughter cells