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. 2024 May 13;20(5):e1012224. doi: 10.1371/journal.ppat.1012224

Fig 3. Disruption of spo0E increases morbidity and early production of toxins during infection.

Fig 3

A) Kaplan-Meier survival curve representing the results from two independent experiments using Syrian golden hamsters inoculated with 5000 spores of C. difficile strain 630Δerm (WT, n = 12) or spo0E mutant (MC1615, n = 13). Mean times to morbidity: WT, 48.7 ± 10.7 h; spo0E, 40.7 ± 17.8 h. **P < 0.001, Log-rank test. B) Total C. difficile CFU/ml of cecal content recovered post-mortem (ns = not significant; unpaired t test). ELISA quantification of TcdA and TcdB toxin per C) gram of fecal sample collected 24 h post-infection or D) per ml of cecal content collected post-mortem. Mid-line indicates median toxin values; unpaired t-test. Data for wild-type infected animals were previously published as part of the manuscript Infect Immun 91:e00319-23.