Table 99.
Human- and mouse-specific and shared NK cell receptors
| Receptor | Ligand | Human | Mouse |
|---|---|---|---|
| KIR2DL1 (CD158a) | Group 2 HLA-C | X | |
| KIR2DL2, KIR2DL3 (CD158b1, -b2) | Group 1 HLA-C, some group 2 HLA-C and some HLA-B | X | |
| KIR3DL1 (CD158e1) | HLA-Bw4 | X | |
| KIR2DS1 (CD158h) | HLA-C2 | X | |
| KIR2DS4 (CD158i) | Some HLA-C1 and HLA-C2, HLA-A11 | X | |
| KIR2DL4 (CD158d) | HLA-G | X | |
| Ly49A (Klra1) | H2-Dd, H2-Dk, H2-Ld, H2-Db, H2-Kb, H2-Dp, H2-M3 | X | |
| Ly49C (Klra3) | H2-Db, H2-Kb, H2-Dd, H2-Kd, H2-Dk | X | |
| Ly49E (Klra5) | Urokinase plasminogen | X | |
| Ly49G (Klra7) | H2-Dd, H2-Kd, H2-Ld, H2-Db, H2-Dk, H2-Dr | X | |
| Ly49I (Klra9) | H2-Kb, H2-Kd, H2-Dk, H2-Kk, m157 (MCMV) | X | |
| Ly49D (Klra4) | H2-Dd, H2-Dr, Dsp2 | X | |
| Ly49H (Klra8) | m157 (MCMV) | X | |
| Ly49P (Klra16) | H2-Dd, H2-Dk, m04 (MCMV) | X | |
| NKG2A (CD159A)/CD94 | HLA-E (human), Qa-1b (mouse) | X | X |
| NKG2C (CD159C)/CD94, | HLA-E (human), Qa-1b (mouse) | X | X |
| NKG2D (CD314) | Human: MICA/B, ULBP1, ULBP2, ULBP3, ULBP4, ULBP5, ULBP6 Mouse: RAE-1a, RAE-1b, RAE-1d, RAE-1e, RAE-1g, H60a, H60b, H60c, MUTL1 | X | X |
| KLRG1 | E-, N-, and R-cadherin | X | X |
| NKp46 (NCR1; CD335) | CFP (properdin), hemagglutinin, PfEMP1 | X | X |
| NKp30 (NCR3; CD337) | B7-H6, BAT3 | X | |
| NKp44 (NCR2; CD336) | 21spe-MLL5 | X | |
| NKp80 (KLRF1) | AICL (activation-induced C-type lectin) | X | |
| DNAM-1 (CD226) | Nectin-2, PVR | X | X |
| 2B4 (CD244) | CD48 | X | X |