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. Author manuscript; available in PMC: 2024 May 23.
Published in final edited form as: Eur J Immunol. 2021 Dec 7;51(12):2708–3145. doi: 10.1002/eji.202170126

Table 51.

Summary murine Tr1 cell phenotype

Marker Relevance for murine Tr1 cell biology
IL-10 Key feature of Tr1 cells, mediates suppression
TGFβ Mediates suppression
LAG-3 Enriches for IL-10-expressing, suppressive cells
TIM-3 Co-expressed with other co-inhibitory receptors on suppressive IL-10+ CD4+ T cells
CTLA-4 Co-expressed with other co-inhibitory receptors on suppressive IL-10+ CD4+ T cells
TIGIT Co-expressed with other co-inhibitory receptors on suppressive IL-10+ CD4+ T cells
PD-1 Co-expressed with other co-inhibitory receptors on suppressive IL-10+ CD4+ T cells
CD49b Co-expression with LAG-3 identifies Tr1 cells
CD226 Is highly expressed by murine Tr1 cells
ICOS Promotes IL-27-induced Tr1 differentiation and IL-10 expression in murine CD4+ T cells
CCR5 expressed by Tr1 cells
CD39/CD73 Mediates suppressive capacity of Tr1 cells
IL10R Maintenance of IL-10 expression and suppressive function of Tr1 cells