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. 2024 Apr 20;65(3):315–322. doi: 10.1093/jrr/rrae012

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© The Author(s) 2024. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3 — Effects of DSB repair inhibitors on the survival and malformation of embryos irradiated after the MBT. (A) Experimental design timeline: embryos were irradiated after the MBT at 7 hpf, 1 h after the addition of inhibitors (NU7026 or RI-1), and incubated with inhibitors from 6 to 48 hpf. (B) NU7026 treatment: left: survival rates; right: malformation rates of embryos treated with NU7026 (a DNA-PKcs inhibitor, open circles) or NU7026 + X-rays (1 Gy, closed circles). (C) RI-1 treatment: left: survival rates; right: malformation rates of embryos treated with RI-1 (a RAD51 inhibitor, open circles) or RI-1 + X-rays (1 Gy, closed circles).