Fig. 3.

Catestatin infusion results in lowering of blood pressure in mice. Systolic blood pressure (SBP) was measured before and 120 min after injection of catestatin (20 nmol/25 g body weight, intraperitoneally; expected to result in a concentration of ~4 μM in the extracellular space) to four chga knock out (chga ^−/−) and four wild-type littermate (chga ^+/+) by telemetry (chga ^−/−). The data for generating this plot were taken from [25]. The data were evaluated by unpaired Student’s t test with the InStat 3 program (GraphPad Software). An exaggerated lowering of SBP was observed in the case of chga ^−/− mice displaying anti-hypertensive effect of the peptide