Fig. 5.

Effects of site-directed transglutaminase 2 inhibitor R281 on a 4-kD macromolecule permeability, b lymphocyte adhesion, and c lymphocyte transendothelial migration in the presence of celiac (CD)- and control patient (non-CD)-derived total IgA. TG2 inhibition blocked the effects of CD IgA on macromolecular permeability (a) and lymphocyte transendothelial migration (c), and attenuated their effect on lymphocyte adhesion (b). Bars represent mean values of experiments performed in duplicate and repeated at least three times. Error bars indicate standard error of means. P < .05 was considered significant