Fig. 6.

Role of Rho activity in response to celiac disease (CD) patient IgA. a RhoA activity in endothelial cells is significantly increased after 24 h administration with CD but not with control (non-CD) patient IgA. Co-administration of the Rho inhibitor C3 endotoxin together with CD IgA abolished the effect of celiac antibodies on the paracellular permeability of 4 kD FITC-dextran (b) and lymphocyte transendothelial migration (d), and diminished lymphocyte adhesion to endothelial cells (c). Bars represent mean values of experiments performed in duplicate and repeated at least three times. Error bars indicate standard error of means. P < .05 was considered significant