Fig. 1.

The desmo-adhesome network. Intrinsic components are represented as squares whilst accessory nodes are circles. Nodes have been assigned different colours according to the function of the respective proteins, as reported in the figure. Binding interactions (non-directional) are represented as black lines with full circles at their end, whereas signalling interactions have blue lines ending with an arrow (activating) or red line with a stop signal at their end (inhibitory). For the relevant nomenclature, please refer to Table 1