Table 1.
Proteins forming the desmosomal interactome
| Gene name | GeneID Entrez | Protein name | ProteinID UniProt | Protein official full name | Functional category | Protein type |
|---|---|---|---|---|---|---|
| CTNNB1 | 1499 | Cnt beta | P35222 | Catenin (cadherin-associated protein), beta 1, 88 kDa | Adaptor | Intr |
| DSC1 | 1823 | Dsc1 | Q08554 | Desmocollin 1 | Membrane | Intr |
| DSC2 | 1824 | Dsc2 | Q02487 | Desmocollin 2 | Membrane | Intr |
| DSC3 | 1825 | Dsc3 | Q14574 | Desmocollin 3 | Membrane | Intr |
| DSG1 | 1828 | Dsg1 | Q02413 | Desmoglein 1 | Membrane | Intr |
| DSG2 | 1829 | Dsg2 | Q14126 | Desmoglein 2 | Membrane | Intr |
| DSG3 | 1830 | Dsg3 | P32926 | Desmoglein 3 | Membrane | Intr |
| DSG4 | 147409 | Dsg4 | Q86SJ6 | Desmoglein 4 | Membrane | Intr |
| DSP | 1832 | DP | P15924 | Desmoplakin | CytoAdapt | Intr |
| EVPL | 2125 | EVPL | Q92817 | Envoplakin | CytoAdapt | Intr |
| IVL | 3713 | IVL | P07476 | Involucrin | Cytoskeleton | Intr |
| JUP | 3728 | PLAK | P14923 | Junction plakoglobin | Adaptor | Intr |
| KRT1 | 3848 | KRT1 | P04264 | Keratin, type II cytoskeletal 1 | Cytoskeleton | Intr |
| KRT10 | 3858 | KRT10 | P13645 | Keratin, type I cytoskeletal 10 | Cytoskeleton | Intr |
| KRT14 | 3861 | KRT14 | P02533 | Keratin, type I cytoskeletal 14 | Cytoskeleton | Intr |
| KRT18 | 3875 | KRT18 | P05783 | Keratin, type I cytoskeletal 18 | Cytoskeleton | Intr |
| KRT2 | 3849 | KRT2 | P35908 | Keratin, type II cytoskeletal 2 epidermal | Cytoskeleton | Intr |
| KRT5 | 3852 | KRT5 | P13647 | Keratin, type II cytoskeletal 5 | Cytoskeleton | Intr |
| KRT6A | 3853 | KRT6A | P02538 | Keratin, type II cytoskeletal 6A | Cytoskeleton | Intr |
| KRT8 | 3856 | KRT8 | Q96J60 | Keratin, type II cytoskeletal 8 | Cytoskeleton | Intr |
| LOR | 4014 | LOR | P23490 | Loricrin | Cytoskeleton | Intr |
| PKP1 | 5317 | PKP1 | Q13835 | Plakophilin-1 | CytoAdapt | Intr |
| PKP2 | 5318 | PKP2 | Q99959 | Plakophilin-2 | CytoAdapt | Intr |
| PKP3 | 11187 | PKP3 | Q9Y446 | Plakophilin-3 | Adaptor | Intr |
| PKP4 | 8502 | PKP4 | Q99569 | Plakophilin-4 | Adaptor | Intr |
| PPHLN1 | 51535 | PPL1 | Q8NEY8 | Periphilin-1 | CytoAdapt | Intr |
| PPL | 5493 | PPK | O60437 | Periplakin | CytoAdapt | Intr |
| CTNNA1 | 1495 | CTNNA1 | P35221 | Catenin (cadherin-associated protein), alpha 1 | Adaptor | Intr |
| CTNNBIP1 | 56998 | CTNNBIP1 | Q9NSA3 | Beta-catenin-interacting protein 1 | Adaptor | Intr |
| KIAA1026 | 23254 | KAZRIN | Q674X7 | Kazrin | Adaptor | Intr |
| AKT1 | 207 | PRKBA | P31749 | RAC-alpha serine/threonine-protein kinase | Kinase | Acc |
| CASP2 | 835 | CASP2 | P42575 | Caspase-2 | Protease | Acc |
| CASP3 | 836 | CASP3 | P42574 | Caspase-3 | Protease | Acc |
| EGFR | 1956 | EGFR | P00533 | Epidermal growth factor receptor precursor | Kinase | Acc |
| ERBB2 | 2064 | ERBB2 | P04626 | Receptor tyrosine-protein kinase erbB-2 precursor | Kinase | Acc |
| ERBB2IP | 55914 | ERBB2IP | Q96RT1 | erbb2 interacting protein | Adaptor | Acc |
| FER | 2241 | FER | P16591 | Proto-oncogene tyrosine-protein kinase FER | Kinase | Acc |
| FURIN | 5045 | FURIN | P09958 | Paired basic amino acid residue cleaving enzyme | Protease | Acc |
| FYN | 2534 | FYN | P06241 | Proto-oncogene tyrosine-protein kinase Fyn | Kinase | Acc |
| KLK5 | 25818 | KLK5 | Q9Y337 | Kallikrein-related peptidase 5 | Protease | Acc |
| MAPK1 | 5594 | MK01 | P28482 | Mitogen-activated protein kinase 1 | Kinase | Acc |
| MAPK3 | 5595 | ERK1 | P27361 | Mitogen-activated protein kinase 3 | Kinase | Acc |
| MARK3 | 4140 | MARK3 | P27448 | MAP/microtubule affinity-regulating kinase 3 | Kinase | Acc |
| MUC1 | 4582 | MUC1 | P15941 | Mucin-1 precursor | Membrane other | Acc |
| PLAT | 5327 | PLAT | Q9BZW1 | Tissue-type plasminogen activator | Membrane other | Acc |
| PRKACA | 5566 | KAPCA | P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Kinase | Acc |
| PRKCA | 5578 | PKCA | P17252 | Protein kinase C alpha type | Kinase | Acc |
| PRKCE | 5581 | PKCE | Q02156 | Protein kinase C epsilon type | Kinase | Acc |
| PRKCZ | 5590 | PKCZ | Q05513 | Protein kinase C zeta type | Kinase | Acc |
| PTPN14 | 5784 | PTN14 | Q15678 | Tyrosine-protein phosphatase non-receptor type 14 | Phosphatase | Acc |
| PTPRF | 5792 | PTPRF | P10586 | Receptor-type tyrosine-protein phosphatase F precursor | Phosphatase | Acc |
| PTPRJ | 5795 | PTPRJ | Q12913 | Receptor-type tyrosine-protein phosphatase eta precursor | Phosphatase | Acc |
| PTPRK | 5796 | PTPRK | Q15262 | Receptor-type tyrosine-protein phosphatase kappa precursor | Phosphatase | Acc |
| SFN | 2810 | 1433S | P31947 | 14-3-3 protein sigma | Adaptor | Acc |
| SPRR3 | 6707 | SPRR3 | Q9UBC9 | Small proline-rich protein 3 | Adaptor | Acc |
| SRC | 6714 | SRC | P12931 | Proto-oncogene tyrosine-protein kinase Src | Kinase | Acc |
| STK24 | 8428 | STK24 | Q9Y6E0 | Serine/threonine-protein kinase 24 | Kinase | Acc |
| TGM2 | 7052 | TGM2 | P21980 | Protein-glutamine gamma-glutamyltransferase 2 | Membrane other | Acc |
| YWHAG | 7532 | 1433G | P61981 | 14-3-3 protein gamma | Adaptor | Acc |