Fig. 4.

Alignment of the amino acid sequence encoding the dentonin region of 35 mammalian MEPE. This 23 amino acid-long region (synthetical peptide AC-100) is located in the central region of MEPE encoded by exon 5 (see Fig. 2). It contains two important motives, RGD and SGDG (boxed), which are preserved in most species. However, RGD is absent in several sequences and the two motives are missing in marsupials. (+) residue identical in all therian sequences. See Fig. 3 for the other symbols