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Putative transcriptional mechanism of ARNT involvement in EGF-induced gene expression. After the stimulation of EGF in normoxia, ARNT accumulates in the nucleus where it interacts with c-Jun and Sp1 to form c-Jun/ARNT/Sp1 complex. These complexes then bind to the Sp1 site of the gene promoter through Sp1 protein and turn on relative gene expression, in which c-Jun transcriptional activity was required. 12-LOX 12(S)-lipoxygenase
