Fig. 12.

Effects of dexamethasone on CSE promoter activity in RAW264.7 macrophages. RAW264.7 cells were treated with dexamethasone at the indicated doses in the absence or presence of RU38,486 (10⁻⁶ mol/l) and LPS (1 μg/ml) for 12 h. CSE promoter activity was assayed as described in “Materials and Methods.” Data were presented as mean percentage of control ± SEM for four independent experiments. **P < 0.01 compared with control; ##P < 0.01 compared with LPS; †P < 0.05 compared with LPS plus dexamethasone. Dex dexamethasone, RU RU38,486