Fig. 7.

Dexamethasone suppressed CSE expression and H₂S production in RAW264.7 macrophages. RAW264.7 macrophages were treated with dexamethasone at the indicated doses in the absence or presence of RU38,486 (10⁻⁶ mol/l) and LPS (1 μg/ml) for 6 h (a) or 24 h (b–d). CSE mRNA (a), protein expression (b, c) as well as H₂S production rates (d) were determined as described in “Materials and Methods.” Data were presented as mean percentage of control ± SEM for a–c (n = 3) and mean ± SEM for H₂S production rates (n = 4). **P < 0.01 compared with control; #P < 0.05, ##P < 0.01 compared with LPS; ††P < 0.01 compared with LPS plus dexamethasone. Dex dexamethasone, RU RU38,486