Table 3.
Binding sites | Isotypes | Inter-isotypic mutations |
---|---|---|
Paclitaxel binding site | III | Ser275-Ala |
VI | Val23-Met, Ser25-Gly, Asp26-Glu, Ser275-Ala, Arg276-Gln | |
Colchicine binding site | III | Cys239-Ser, Ala315-Thr, Thr351-Val |
V | Cys239-Ser, Ala315-Thr, Thr351-Val | |
VI | Val236-Ile, Cys239-Ser, Ala315-Thr, Thr351-Val | |
Vinblastine binding site | III | Thr218-Ala |
Substitutions observed between βI and the other human β-tubulin isotypes in paclitaxel, colchicine, and vinblastine binding sites