Fig. 2.

Pfnek3 possesses a MAPKK-like activation site within its activation loop. Top The Pfnek3 amino acid sequence corresponding to the putative activation loop is illustrated. The underlined SSEQSS motif bears a resemblance to the SXXXS/T activation sites of MAPKKs. Bottom The Pfnek3 model was generated using SWISS-MODEL and subsequently compared with the crystal structure of human MEK1 (1S9J). The putative activation loop of Pfnek3 is highlighted in yellow. The SSEQSS motif was observed to locate at the surface of this loop and reside in a position analogous to the SMANS activation site of human MEK1 (both boxed up in blue)