Fig. 5.

Numbers of interactions (upper panel) and the sum of vdW and Coulombic energy terms [19] per each residue (lower panel) calculated from the X-ray structure of hCyP19 (1QOI.pdb) with written patches of sequences that are crucial for the PPIase cavity and the aromatic/hydrophobic AAs network; red dashed line was arbitrarily placed to indicate the largest energy contributions. The upper parts of the sequence patches come from hCyP19 whereas lower parts were taken from the sequence of hCyPA