Table 2.
The expressed forms of the human cyclophilins and some of their biological functions
| No. | Protein name (alias) | Code | PDB | Chromosome/gene | Naa | Mass (Da) | Entire protein | CLD | Extra- domain |
B_Pra | Cellular localization and biological functionsb |
Reference | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| pI | HI | CLD-length | pI; HI | |||||||||||
| 1 | CyP18a (hCyPA) | NP_066953 | 2CPL | 7p13-p11.2/PPIA | 165 | 18013 | 7.8 | 37.6 | Full | St | (C/S) Immunosuppression | [1–4, 11–15] | ||
| Cell-related events | [66, 67] | |||||||||||||
| HIV-1 replication | [68, 69] | |||||||||||||
| HCV replication | [70, 71] | |||||||||||||
| 2 | CyP18b* | NP_839944 | 1q21.1/PPIAL4G | 164 | 18182 | 9.6 | 34.1 | Full | Un | (N) Oncogene | [72] | |||
| 3 | CyP18c (hCyPJ) | NP_115861 | 1XYH | 2q33.1/PPIL3a | 165 | 18627 | 6.6 | 27.3 | Full | Un | (N) Spliceosome | [73] | ||
| 4 | CyP18ci | NP_570981 | 2q33.1/PPIL3b | 161 | 18155 | 6.3 | 27.3 | Full | Un | (N) Spliceosome | [73] | |||
| 5 | CyP18d (CGI-124) | NP_057143 | 1XWN | 6p21.1/PPIL1 | 166 | 18237 | 8.2 | 33.7 | Full | Un | (N) Spliceosome, cancer growth | [73, 74] | ||
| 6 | CyP22b/p (hCyPB) | NP_000933 | 1CYN | 15q21-q22/PPIB | 208 | 22742 | 9.8 | 42.3 | 26-208 | 9.7; 38.3 | St | (ER/S) Protein folding | [5] | |
| TPRV6 channel-associated | [75] | |||||||||||||
| 7 | CyP22C/p (hCyPC) | NP_000934 | 2RMC (Mm) | 5q23.2/PPIC | 212 | 22763 | 8.7 | 52.8 | 28-208 | 9.4; 48.1 | St | (Memb) Unknown | [76] | |
| 8 | CyP22D/p (hCyPF) | NP_005720 | 2BIT,2Z6 W | 10q22-q23/PPIF | 207 | 22040 | 9.8 | 39.1 | 36-207 | 9.3; 35.8 | St | (Mito) Mitochondrial pore | [77] | |
| Mitochondria/Muscular dystrophy | [78] | |||||||||||||
| Hexokinase II/apoptosis | [79] | |||||||||||||
| Mitochondrial function | [80] | |||||||||||||
| 9 | CyP19 (hCyPH) | NP_006338 | 1MZW,1Q0I | 1p34.1/PPIH | 177 | 19208 | 8.1 | 44.1 | Full | St | (N) Spliceosome | [73] | ||
| Pre-RNA splicing | [81] | |||||||||||||
| 10 | CyP33 (hCyPE) | NP_006103 | 1ZCX,1ZMF | 1q32/PPIE | 301 | 33431 | 5.3 | 33.2 | 130-301 | 8.4; 32.0 | RRM | St | (N) RNA-binding/spliceosome | [82] |
| 11 | CyP35 (hCyP35) | NP_775943 | 6q21/PPIL6 | 311 | 35228 | 6.6 | 35.0 | 140-311 | 7.6; 35.5 | RRM | Un | (N) Organism growth | [83] | |
| 12 | CyP40 (hCyPD) | NP_005029 | 1IIP (Bt) | 4q31.3/PPID | 370 | 40764 | 6.8 | 31.6 | 6-192 | 6.8; 38.0 | TPR | Wk | (C) HSP-steroid receptor | [84] |
| 13 | CyP46 | NP_689542 | 14q21.1/PPIL5 | 414 | 46723 | 9.3 | 48.3 | 90-360 | 9.2; 43.5 | LRR | Un | (C/N) Signal transduction | [85] | |
| 14 | CyP54 | NP_005860 | 5q12.3/SDCCAG10 | 472 | 53847 | 5.5 | 16.3 | 1-180 | 5.6; 31.7 | WD40 | Un | (N) Cancer marker/spliceosome | [86] | |
| 15 | CyP57 | NP_624311 | 6q24-q25/PPIL4 | 492 | 57225 | 5.6 | 20.9 | 1-165 | 5.0; 33.9 | RRM | Un | (N) Spliceosome | [87] | |
| 16 | CyP58 (hCyP60) | NP_680480 | 1ZKC | 22q11.21/PPIL2 | 520 | 58824 | 9.0 | 22.5 | 271-446 | 8.6; 22.7 | RING | St | (N) Spliceosome | [73] |
| 17 | CyP73 | NP_056157 | 2A2 N | 5q12.3/PPWD1 | 645 | 73444 | 6.7 | 32.7 | 476-645 | 6.8; 30.0 | WD40 | Un | (N) Spliceosome | [73] |
| 18 | CyP88 (hCyPG) | NP_004783 | 2GW2 | 2q31.1/PPIG | 754 | 88618 | 10.7 | 8.5 | 1-184 | 8.4; 34.8 | SR | St | (N) Spliceosome | [88] |
| 19 | CyP157 | NP_005376 | 2HE9 | 3p23-p11/NKTR | 1403 | 157712 | 10.3 | 13.3 | 51-238 | 8.3; 37.2 | SR | St | (N) Spliceosome | [89] |
| 20 | CyP358 | NP_006258 | 2q11-q13/RANBP2 | 3224 | 358221 | 5.8 | 25.7 | 3024-3224 | 6.7; 35.9 | Nup | Un | (N) Nucleoporin | [90, 91] | |
aOverall binding capacity of the cyclophilins: strong (St) for Kd or Ki ≤ 50 nM, weak (Wk) for these two values larger than 400 nM, and unknown (Un) if no experimental value was established
bKnown cellular localizations: N nuclear, C cytoplasmic, S secreted form, Memb membrane associated, Mito mitochondrial protein