Table 1.

Summary of ING family effects on cancer progression

Member	ING expression	Progression implication	Study type	Cancer type	Reference
ING1	Low	Lymph node metastasis	In vivo	Breast	[36]
	Low	Tumor progression	In vivo	Melanoma	[38]
	Low	Distant metastasis	In vivo	Stomach	[23]
	High	Lymph node metastasis	In vivo	OSCC	[39]
ING2	Low	Metastasis	In vivo	Melanoma	[48]
	High	Invasion	In vitro	Colorectal	[46]
ING3	Low	Metastasis	In vivo	Melanoma	[55]
	Low	TNM stage	In vivo	HNSCC	[72]
ING4	Low	NF-κB activity	In vitro/in vivo	Glioma	[89]
	Low	HIF-1 activity	In vitro	Cervical	[87]
	Low	HIF-1 activity	In vitro	Myeloma	[88]
	Low	Migration	In vitro	Colon	[95]
	Low	Metastasis	In vivo	Melanoma	[76]
	High	p53 Activity	In vitro	Colon	[93]
	High	Metastasis	In vitro	Breast	[83]
	High	Migration	In vitro	Colon	[95]
	High	Invasion, migration	In vitro	Melanoma	[76]
	High	Invasion	In vitro	Glioma	[90]
	High	Invasion	In vitro	Lung	[79]
ING5	High	p53 Activity	In vitro	Colon	[93]

OSCC oral squamous cell carcinoma, HNSCC head and neck squamous cell carcinoma