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Cell communication between osteoclasts and osteoblasts. After completion of bone resorption, osteoclasts make contact with osteoblasts. Apoptosis of osteoclasts and proliferation of osteoblasts are induced by bidirectional signaling of ephrinB2–EphB4, which are expressed by osteoclasts and osteoblasts, respectively. Osteoblasts proliferate due to the action of growth factors released from the bone matrix
