Fig. 1.

The human KLF5 gene and protein structures. The human KLF5 genome contains four exons (exon 1, 585 bp; intron 1, 2,272 bp; exon 2, 874 bp; intron 2, 1,089 bp; exon 3, 60 bp; intron 3, 11,824 bp; and exon 4, 1,831 bp). The KLF5 protein contains three zinc-finger (ZF) domains, one major transactivation domain (TAD) with a PY motif (PPSY328), and a nucleus export signal (NES). The KLF5 protein undergoes different types of posttranslational modifications, including phosphorylation (P at S153), acetylation (Ac at K369), ubiquitination (Ub), and sumoylation (Su at K162 and K209)