Intestine and colon |
mRNA expression is decreased in APCmin mouse adenomas and familial adenomatous polyposis |
Promotes cell proliferation |
[51, 73, 74, 79, 101] |
Breast |
Gene copy number loss. mRNA is low in ER + cancer cell lines, high in ER-tumors |
Promotes MCF7 xenograft growth |
[36, 84, 110] |
Prostate |
Gene copy number loss. mRNA is lost in some cancer cell lines |
Inhibits DU145 and 22Rv1 colony formation |
[78, 111] |
Overexpression in some prostate cancers |
Bladder |
mRNA is upregulated and downregulated in cancer cell lines but not in tumor samples |
Promotes TSU-Pr1 xenograft growth |
[20, 40] |
Leukemia |
mRNA is upregulated and downregulated in cancer cell lines and acute lymphoblastic leukemia by Northern blot |
Promotes EU-4 resistance to doxorubicin |
[45] |
Esophageal |
mRNA level is high in stem-like cancer cells by qRT-PCR |
Inhibits cell proliferation, survival, and invasion. Promotes basal cell proliferation in KLF5 Tg mice |
[77, 102, 112] |
Salivary gland |
Gene copy number gain by CGH |
|
[108] |
Gastric cancer |
Protein expression is high in early-staged, lymph node metastasis negative, and small sized tumors by IHC |
|
[109] |
Nasopharyngeal |
mRNA is down-regulated by microarray |
|
[138]. |
Melanoma |
mRNA is down-regulated in two Ras mutated cancer cell lines by microarray |
|
[139] |