Table 3.

The role of KLF5 in different types of cancer

Cancers	Genetic and expression	Function	References
Intestine and colon	mRNA expression is decreased in APCmin mouse adenomas and familial adenomatous polyposis	Promotes cell proliferation	[51, 73, 74, 79, 101]
Breast	Gene copy number loss. mRNA is low in ER + cancer cell lines, high in ER-tumors	Promotes MCF7 xenograft growth	[36, 84, 110]
Prostate	Gene copy number loss. mRNA is lost in some cancer cell lines	Inhibits DU145 and 22Rv1 colony formation	[78, 111]
	Overexpression in some prostate cancers
Bladder	mRNA is upregulated and downregulated in cancer cell lines but not in tumor samples	Promotes TSU-Pr1 xenograft growth	[20, 40]
Leukemia	mRNA is upregulated and downregulated in cancer cell lines and acute lymphoblastic leukemia by Northern blot	Promotes EU-4 resistance to doxorubicin	[45]
Esophageal	mRNA level is high in stem-like cancer cells by qRT-PCR	Inhibits cell proliferation, survival, and invasion. Promotes basal cell proliferation in KLF5 Tg mice	[77, 102, 112]
Salivary gland	Gene copy number gain by CGH		[108]
Gastric cancer	Protein expression is high in early-staged, lymph node metastasis negative, and small sized tumors by IHC		[109]
Nasopharyngeal	mRNA is down-regulated by microarray		[138].
Melanoma	mRNA is down-regulated in two Ras mutated cancer cell lines by microarray		[139]