Table 1.

Putative role of proteases in melanoma

Class	Name	Role	Reference
Metallo-proteinase	MMP-1	Tumor progression, tissue marker for progression	[38]
	MMP-2	Tumor progression, tissue marker for melanoma-specific mortality	[39, 63]
	MMP-3	Tumor progression, tissue marker for progression	[38]
	MMP-7	Melanocyte differentiation marker	[59]
	MMP-8	Host defence, serum marker	[50]
	MMP-9	Malignant transformation or tumor progression	[51, 54]
	MMP-12	Host defence	[56]
	MMP-13	Invasion	[45]
	MMP-21	Malignant transformation	[46]
	MT1-MMP	Invasion	[39]
	ADAM-9	Invasion	[49]
	CD10/neutral endopeptidase	Tissue marker for progression	[48]
Inhibitor	TIMP-1	Tumor progression	[57]
	TIMP-3	Tumor progression	[57]
Serine protease	uPA	Tumor progression, marker for malignancy	[79, 80]
	tPA	Proliferation	[83, 87]
	CD26/DPP IV	Melanocyte differentiation marker	[90]
	DPP II	Proliferation	[88]
Inhibitor	Maspin	Marker for benign lesions, suppressor of proliferation and invasion	[92]
	PAI-1	Tumor progression, blood marker for malignancy	[79, 96]
Cysteine protease	Cathepsin A	Transformation	[125]
	Cathepsin B	Tumor progression	[106]
	Cathepsin D	Malignant transformation	[123]
	Cathepsin L	Tumor progression	[107]
	Cathepsin K	ECM degradation	[126]
	Cathepsin E	Host defense	[127]
	Cathepsin H	Host defense	[91]
Inhibitor	Cystatin C	Host defense	[118]