Table 1.

Comparison of molecular characteristics of the four human WNK genes and their expression

Gene	Chromosome	Size (Mb)	Exon nb.	Codons	MW (kDa)	Expression in tissues	Other features	References
WNK1	12p13.3	150	28	2,382	251	Widespread	Alternative splicing in exons 9, 11 and 12.	[5, 6, 73, 103, 113]
							Multiple Promoters	[102]
WNK2	9q22.31	136	31	2,297	243	Brain, heart, colon	Alternative C-terminal exon (either 30 or 31)	[17, 103]
WNK3	Xp11.23–21	165	24	1,743	192	Brain, liver, small intestine	Alternative splicing in exons 18 and 22	[86, 103, 107, 114]
WNK4	17q21–q22	16	19	1,243	135	Kidney, skin, colon, liver, lung	Not described	[73, 79, 103]