Table 2.

List of somatic WNK mutations identified in different unbiased cancer genome sequencing efforts (corresponding references are indicated)

Tissue	Histology/type	Gene	Zygosity	cDNA	Protein	Mutation	References
Breast	Pleomorphic lobular carc.	WNK1	Hetero	c.1255G>C	p.E419Q	Missense	[109, 111]
Breast	IDC	WNK1	Hetero	c.5395C>G	p.Q1799E	Missense	[109–111]
Breast	Pleomorphic lobular carc.	WNK1	Hetero	c.6569C>G	p.S2190C	Missense	[109, 111]
Ovary	Serous carcinoma	WNK1	Hetero	c.2829C>T	p.Y943Y	Silent	[111]
Colon	Colorectal	WNK1	Hetero	c.3596A>G	p.E1199G	Missense	[110]
Brain	Glioblastoma	WNK1	Hetero	c.5293G>A	p.G1765S	Missense	[112]
Lung	Adenocarcinoma	WNK1	Homo	c.7086C>A	p.F2362L	Missense	[108, 111]
Colorectal	Adenocarcinoma	WNK2	Hetero	c.1964delC	p.P655 fs*2	Frameshift deletion	[111]
Brain	Glioblastoma	WNK2	Hetero	c.3799G>A	p.A1267T	Missense	[112]
Stomach	Adenocarcinoma	WNK2	Hetero	c.4269delC	p.S1424 fs*5	Frameshift deletion	[111]
Lung	Neuroendocrine carcinoma	WNK2	Hetero	c.5009G>A	p.G1670E	Missense	[108, 111]
Lung	Adenocarcinoma	WNK2	Hetero	c.6089G>T	p.S2030I	Missense	[108, 111]
Ovary	Serous carcinoma	WNK2	Hetero	c.1528G>T	p.V510L	Missense	[111]
Ovary	Mucinous carcinoma	WNK2	Hetero	c.6798delC	p.T2267 fs*31	Frameshift deletion	[111]
Glioma	Glioblastoma	WNK3	Hetero	c.2784C>T	p.H928H	Silent	[111]
Lung	Squamous cell carcinoma	WNK3	Hetero	c.2561C>G	p.S854C	Missense	[111]
Lung	Large cell carcinoma	WNK3	Hetero	c.4599G>T	p.L1533F	Missense	[111]
Kidney	Clear cell carcinoma	WNK3	Hetero	c.3809C>A	p.T1270 N	Missense	[111]
Kidney	Clear cell carcinoma	WNK3	Hetero	c.4900T>C	p.S1634P	Missense	[111]
Ovary	Mucinous carcinoma	WNK4	Hetero	c.1338C>G	p.D446E	Missense	[111]
Melanoma	Metastatic	WNK4	Hetero	c.1438C>T	p.L480L	Silent	[111]
Melanoma	Not described	WNK4	Hetero	c.3010C>T	p.P1004S	Missense	[111]
Melanoma	Not described	WNK4	Hetero	c.3190C>T	p.P1064S	Missense	[111]
Stomach	Adenocarcinoma	WNK4	Hetero	c.1822delG	p.V608 fs*53	Frameshift deletion	[111]

Note that the nucleotide and codon designations of WNK2 and WNK4 mutations described in [108, 111] required correction because they were based on incomplete protein sequences. Because the sequence context for each of the mutation described in these references is available online at http://www.sanger.ac.uk/perl/genetics/CGP/cgp_viewer?action=bygene&letter=W&mutant=1, the mutations could be unambiguously localised in the full length cDNA and protein sequences, allowing correction of their designations (as full length reference sequences, we used Ensembl gene IDs ENST00000315939 (WNK1), ENST00000297954 (WNK2), ENST00000354646 (WNK3) and ENST00000246914 (WNK4), all available at http://www.ensembl.org/index.html)