Fig. 1.

X-ray structure of the human septin complex SEPT2–SEPT6–SEPT7. SEPT2–SEPT6–SEPT7 filament is arranged with alternating G-dimer interfaces and NC-dimer interfaces. Bound guanine nucleotide is also observed in the SEPT2–SEPT6–SEPT7 filament; both SEPT2 and SEPT7 are GDP-bound, while SEPT6 is GTP-bound. The NC-dimer interfaces and the G-dimer interfaces are indicated with black arrows and red arrows, respectively. The dashed arrows indicate the position and orientation of the coiled-coil domain. This figure is reproduced with the kind permission of the authors Sirajuddin et al. [38]