Table 1.
Posttranslational modification of Drp1
| Regulator | Modification | Functional effect | Reference |
|---|---|---|---|
| CDK1 | Phosphorylation at Ser 618 | Increase | [29] |
| PKA | Phosphorylation at Ser 637 | Decrease | [27, 46] |
| CaMKIα | Phosphorylation at Ser 600 | Increase | [32] |
| CDK5 | Phosphorylation | Increase | [48] |
| Calcineurin | De-phosphorylation at Ser 637 | Increase | [47] |
| Nitric oxide | S-Nitrosylation at Cys 644 | Increase | [33] |
| SUMO1 | Sumorylation | Increase | [24, 50] |
| SENP5 | De-sumorylation | Decrease | [24, 31] |
| MAPL | Ubiquitination | Increase | [53] |
| MARCH5 | Ubiquitination | Increase/decrease | [51, 52] |