Fig. 4.

The IL-22/IL-22R1, IL-22/IL-22BP, and IL-10/IL-10R1 binary complex interfaces. a IL-22/IL-22R1 (PDB entry 3DLQ [28]). b IL-22/IL-22BP (PDB entry 3G9V [150]). c IL-10/IL-10R1 (PDB entry 17JV [117]). The cysteine residues involved in disulfide bonds are shown as light grey sticks and labeled. Sites 1a and 1b are highlighted and amplified. The potential polar contacts are displayed as dashed lines, with the hydrogen bonds in yellow and the ionic interactions in red. The selected water molecules are shown as red spheres. Oxygen atoms are shown in red, nitrogen in blue, and sulfur in yellow. Figures were generated with the PyMOL software (DeLano Scientific)