Fig. 5.

Oligomeric assembly and electrostatic potential in hexameric NMNATs viewed along the three-fold axis. Positive and negative electrostatic potential are represented in blue and red, respectively. a M. jannaschii NMNAT. b Human NMNAT1 (PDB code 1KKU). For one of the subunits, the region not visible in the crystal structure due to high conformational flexibility is indicated by a dotted line. The sequence of the nuclear localization sequence (NLS) is indicated with the residue subjected to phosphorylation (Ser136) in red