Fig. 1.

Combinatorial action of Sox2 and its partner proteins on regulatory enhancers. a Sequences of Sox-dependent regulatory regions of FGF-4 and δ-crystallin genes. b Selective recruitment of the Oct-3/4–Sox2 complex by the UTF1 regulatory region. The UTF1 regulatory enhancer serves as a specific binding site for Oct-3/4–Sox2 complex, but prevents similar protein complexes, such as Oct-1–Sox2, from binding to the variant Octamer sequence (for details, see reference [21])