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PI(4,5)P2 metabolism and activity. PI(4,5)2 is generated mainly by phosphorylation of PI(4)P by PIP5KI (the pathway indicated by thicker arrows) and, to lower extend, by PIP4KII-catalyzed phosphorylation of PI(5)P. PI(4,5)2 directly affects activity of numerous proteins, serves as a source of second messengers: IP3, DAG, and PI(3,4,5)P3. The lipid can be also dephosphorylated at the D-4 and D-5 positions of the inositol ring
