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Transgenic mice overexpressing human Epo only in brain (tg21) does not show activation of Janus tyrosine kinase 2 (JAK-2) or corresponding downstream signal factors such as signal transducers and activators of transcription (STAT-5), extracellular-regulated kinase (ERK-1/-2), jun kinase (JNK), or serin/threonin kinase (AKT)
