Table 3.
Antigen, Culture, and Imaging Findings.
|
Patient
No. |
Antigen | Culture | Bacterial species | Brain lesion on MRI | Airway or lung lesion | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| CSF (titer) | Blood | CSF | Blood | Each hospital | NIID | |||||
| 1 | 1:8* | (+) | (-) | (+) | C. neoformans | C. gattii** | Cyptococcoma | (+) | ||
| 2 | 1:512 | 1:512 | (-) | (-) | (-) | N/A | Ventriculomegaly | (+) | ||
| 3 | 1:256 | (+) | (+) | (-) | C. neoformans | C. neoformans | Gd enhanced nodular lesions in parietal lobe, brain stem, cerebellum | (-) | ||
| 4 | >1:512 | (+) | (+) | (+) | C. neoformans | N/A | Gd hyperintensity lesions along the pia mater stroke | (-) | ||
| 5 | >1:512 | (+) | (+) | (-) | C. neoformans | N/A | (-) | (-) | ||
| 6 | N/A | (+) | (-) | (-) | (-) | N/A | (-) | (-) | ||
| 7 | (-) | (+) | (-) | (-) | C. neoformans** | N/A | Cryptococcoma Gd enhanced lesions along the pia mater soap bubble appearance | (+) | ||
| 8 | (+) | (+) | (+) | (-) | C. neoformans | N/A | Gd enhanced lesions along the pia mater and nodular lesions in left basal ganglia FLAIR hyperintensity lesions in cerebral white matter hydrocephalus | (-) | ||
| 9 | >1:512 | (+) | (+) | (+) | C. neoformans | C. neoformans | Hydrocephalus | (+) | ||
* After treatment.
**Lung tissue sample.
CSF: cerebrospinal fluid, NIID: National Institute of Infectious Diseases, MRI: magnetic resonance imaging, N/A: not available, Gd: gadolinium, FLAIR: fluid-attenuated inversion recovery, C. neoformans: Cryptococcus neoformans, C. gattii: Cryptococcus gattii